Biochemistry WGU

Oxygenated vs deoxygenated states of blood: One hemoglobin can carry 4 oxygen Deoxygenated hemoglobin is not bound to oxygen If a person has low oxygen level, a bluish hue will result and a low pulse oxygenation will register as a measurement of the difference between oxygenated and deoxygenated hemoglobin. *†Hemoglobin transports oxygen to cells and C02 to lungs to be exhaled. **Deoxygenated hemoglobin is concave shape; oxygenated is planar shape and red in arteries Hemoglobin (2013) Bohr Effect Lower blood pH or higher blood C02 = hemoglobin proteins – oxygenLower C02 or higher pH = hemoglobin + oxygen Myoglobin has no allostery, does not display Bohr effect High C02, high H+, low partial = oxygen from hemoglobin High C02 or low pH = increase of oxygen in tissues Bohr Effect (2013) Oxygen Affinity and pH Bohr Shift Carbonic acid = lower blood pH Lower blood pH = Bohr Shift (oxygen from hemoglobin) wolfe (2000) Hemoglobin and Myoglobin Myoglobin Binds iron, stores oxyge n ‘OF2 ADnormal, result 0T an Injury to muscle Myoglobin = heme + iron + 8 amino acid chains in alpha helix HemoglobinTransports oxygen from lungs to tissues Contains iron (Hemoglobin 2013) Sickcle Cell Abnormal, sickle cell shaped RBC's Sickle cells stop blood flow, very painful Problem: valine in place of glutamic amino acid causing cells to stick together Problem: cells are rigid and inflexible Problem: normal RBC's live 90-120, sickle cells live 10-20 days, shorter lifespan results in anemia Inheritance Autosomal recessive disease inherited from parents Carrier parents will produce offspring with a 1:4 chance of inheriting sickle cell disease .

Credit Card Debt

Many people use credit cards and most of the time the credit card is not used in the right moment. I believe that credit cards are not beneficial because they aren't used for the right things. It would be very different if they were used correctly, credit cards are to be used it case of an emergency,meaning not to be used when you are going to the 7-eleven to buy a bag of chips an a soda. It has shown that more than 75% percent of americans have been bankrupt or on the verge of it.There are more than 60% of americans that have credit card debt because they are using them for the wrong things. Facts have proven that the total U. S. credit card debt, is $793. 1 Billion. and Average credit card debt per household is 15,799. Most people do not understand that when you have a credit card it comes with alot of responsibility and i say that because there are more than 10% of americans have been victims of credit card theft it may not seem like alot but credit card theft is a very serious th ing.Most complaints come from adults within the ages 40-59, Nevada, Colorado, and New Hampshire have the highest rate of credit card fraud. Having a credit card is not what people think it is; people think that if i have a credit card then i do not have to have money with me, and its just free money but its very dangerous to have a credit card. Having a credit card can lead to bankrupt and going bankrupt can make you lose everything such as your car, house, and etc. , or it could be worse an you could be placed in jail for a long time.Just because you had a credit card and used it for the wrong thing and spent way to much money†¦ A credit card is nothing but trouble each and every type of way. The credit card companies and banks are getting richer, while most Americans are getting more in debt. The economy is in trouble, therefore, more and more people are relying on credit cards. In today's society we are constantly trying to get out of debt, but in the process of trying to ge t ourselves out of debt, we create more debt.One of the major problems that most of us are dealing with is credit card debt. Most credit card companies are not looking out for your best interest. They are constantly raising interest rates. Minimum payments are just enough to cover the finance charges. Most Americans should not use credit cards for the following reasons: it will create bad spending habits; you will incur more debt affecting credit score rating; and possibly make you a victim of identity theft.In my opinion, a credit card should be used for purchases that you are able to pay off in full upon receiving your statement, but most of us don't. Most people lack self control and tend to misuse the credit card. Credit cards should mainly be used for emergencies, but we tend to use them for everyday purchases such as: food, gas, clothing, etc. Some people are living in a borrowed lifestyle, because they purchase things they can't afford. People will spend more on a purchasing using a credit card than they would with cash. People that use credit cards tend to spend 12%-18% more on transactions than those who use cash (faithfitnessfinance. com). † For example, if you are going to pay with a credit card in a fast food establishment, it is easier to get the large drink instead of the medium drink. When the statement arrives, most people will make the minimum payment on his/her credit card. The minimum payment only covers the finance charges, which will increase the amount of time it will take to pay the debt off. â€Å"It will also increase the amount of interest you end up paying

Cat in the Rain Essay Example for Free (#2)

Cat in the Rain Essay Cat in the Rain is a short story about an American couple on vacation to Italy. They are in their first year of marriage. The husband has a dismissive attitude towards the wife and the wife always wants more. In the story the couple has a lot of selfishness going on in their relationship. The husband ignores his wife’s needs and the wife and the wife is not satisfied with her husband. The theme of this story has a lot to do with loneliness in the couples’ relationship. In this story the American couple is trapped in their hotel room with nothing to do because of the raining weather. The husband wants to read and ignore his wife. So the wife is looking out the window and sees a cat crouched from the rain. She wants to go downstairs and get the cat. She tells her husband about it and he shrugs it off. The wife goes down herself and the story talks a lot about how she likes the inn keeper. I find that this part of the story most affected me when the husband ignored his wife’s wants and needs. She really wanted that cat because it was something for her to do and feel good about. Her husband obviously doesn’t satisfy her which makes her feel lonely and the cat would keep her company. The wife in this story wants to feel appreciated and loved like any other woman would. Being married for their first year is beginning to be hard for them. Hemingway tries to tell about a first marriage of a couple he once knew and how hard it is for some to always keep that happiness. Couples always have disagreements but should never feel alone. A husband should not ignore his wife’s needs and in this story that is what he does instead of trying to satisfy his wife. Close to the ending of this story the wife was not able to find the cat. She came back in the hotel room very sad. She tries to tell her husband but he does not listen. She starts complaining about what she wants to change about herself. She wants â€Å"her hair to be long so she can brush it† and she wants a cat. The husband can only say that he likes things the way they are. He tells her to shut up. He does not care what the wife’s needs are or what she wants. He does not want to listen and he just wants to read which is what he wishes she would do. This part of the story really interested me because I could not get as to why the husband doesn’t respond to what she asks for. The wife desperately wants attention and he is not giving it to her. The story of the American couple explains a lot about how the wife tries to get attention from the husband. Hemingway talks about a cat but behind that cat this story means more. The lack of attention her husband gives her may make her feel that she is restricted on expressing herself and keeps most of her feelings inside. The cat stays compact to stay dry outside, which is how the wife feels she has to be with her husband to make him happy. She hides herself constantly from him. In this story it relates to her as American wife and never tells her name. This kind of says that she is nothing but an American wife which is exactly how she feels. Hemingway had a unique way of telling the story but the way he told it had a lot of meaning to it. He showed the couples loneliness in a different way. Cat in the Rain. (2016, Dec 19).

Autobiography(first love) Essay Example | Topics and Well Written Essays - 500 words

Autobiography(first love) - Essay Example On the morning of May 27th, I finally got my chance to do something about the way I felt. It was announced that my school would be starting later than usual that morning, which would give me a chance to go over to her school instead. I thought about what I was going to do for the rest of the day, even during my night-time tutoring session at the Educational Institution, where I was learning English. I saw someone selling flowers, which gave me a tremendous idea. I bought sixteen roses, one for every year of her life, and hid them in my garden so that my parents wouldn’t see them. When I got home, I called a couple of my friends to see if any of them would go with me – I didn’t want to be alone. The next morning didn’t go quite the way I’d planned. I was anxiously waiting at the bus stop for the two friends that said they would go with me and they managed to get there just before the bus to her school. I still regret my choice of clothing for this meeting. I was going to have to go straight from her school to mine, so I was wearing our horrible brown school uniform. We looked like janitors, which was sure to work against me. My planning skills were found to be poor again when we arrived at her school and I realized I had no idea where her classroom was. While we searched from classroom to classroom, we ran into one of the teachers, who recognized that we didn’t belong at that school. He thought we were there to make trouble, so he hit us and banned us from the grounds. One of my friends didn’t want to risk getting in trouble for a girl that wasn’t even for him, so he waited outside while my other friend and I tried to get back through the gates. Although there hadn’t been a guard there before, there was one now and he stopped us to ask why we were trying to get inside. The roses probably should have made it possible for him to guess, but my friend lied and said we wanted to make one of the teachers feel better. He

Operations Management Assignment Example | Topics and Well Written Essays - 1250 words

Operations Management - Assignment Example A business that has an effective management strategy is likely to have an upper hand in the market. There are diverse benefits associated with efficient operations management, including a reduction in the operational costs while enhancing customer satisfaction. Inventory management ensures that sales, customer service, and production are done effectively without interruptions, hence ensuring customer satisfaction and cost reduction. In addition, optimizations of inventory levels as well as helping in improving cash flows are major benefits derived from inventory management. Improper inventory management can lead a business to huge losses. In the modern context, several inventory management controls have been developed; some that are highly sophisticated while others are quite simplistic. Some of the available inventory management tools include ABC analysis, Economic Order Quantity (EOQ), Discounted EOQ, Vendor managed Inventory (VMI), LP, MRPII, TQM, ERP, KANBAN, and collaborative pl anning among others. Inventory management tools are very well applied in organizations for diverse purposes. A number of company operations are associated with the inventory management tools. Firstly, in the process of developing the company accounts, the accuracy is tremendously improved hence enhanced reporting of the company profits and losses (Silver 2008, p.16; Hilton1994). This is done based on the asset value that is attached to every item that is purchased, those within the company and the ones sold. Secondly, the management is able to identify flaws and ensure they are rectified before they get out of hand. The inventory management tools help track all the items in the company, thereby ensuring that flaws do not accrue until the stock taking date. Fourthly, customers are very important people as far as the company is concerned. The inventory management tools are able to identify items that are in shortage hence customers are able to make their bookings without being

Source Selection and Ethical standards Applied on the Supply Chain Essay

Source Selection and Ethical standards Applied on the Supply Chain Performance - Essay Example This generally involves having a budget for the items needed, selecting the supplies intended in this bandages, needles, medical equipment etc. This is followed by the bidding process where the bidders are invited to tender for the supplies. The selection of the most viable and convenient supplier is chosen, implementation is done and further follow up is carried out. Triage approach is one the suggested ways that thoroughly looks at a systematic evaluation of individual suppliers then gives them categorical differences (Robert et al, 2008). This process enables you to get the best deal in inventory management process by assessing the suppliers’ dealings. It also customizes the product needs according to specifications let alone the strategic location that is convenient for you. The opportunity presented here is in product specification delivery. There is often a team that is liable to undertake the whole process. The sales lead oversees everything to the customers’ fin al detail. The procurement team and the technological advancement team plus the consultant team work hand in hand to meet the customers’ target. The team will always be ready to make any amendments and give suggestions towards vital changes that would be beneficial to the hospital. The location as well the timing is all put in consideration. The price at which the customer is willing to pay is negotiated and the fairest price reached. This saves on time as well the costs involved in other modes of procurement. This is because a shortage of inventory is not felt as well as the stock levels are maintained at the recommended levels. No one time will you experience out of stock of your supplies since your target is at the core of the supplier chain manager. The whole source selection caters for production, delivery, inventory management, locality aspects, and providing information where need be. The advantages of the source selection are so beneficial to the hospital. Insourcing is recommended than outsourcing. Outsourcing of the source needs would and might incorporate all the clientele needs. The small details that are vital in such a process may be overlooked leading to failure of the whole process. The cost involved in getting a consultant to outsource may also be quite high as the work is tedious. On the contrary the outsourcing of the source needs may be beneficial in that it will not consume time for the management. The whole process is left to the consulting company. The final decision however rests with the management. Insourcing of the source needs is recommended due to the fact that the needs are clarified along the way. Any changes that need to be made are done quickly saving on time. The best opportunity can easily be identified as the direct involvement is between the supplier and the hospital. A thorough analysis can be made before the selection process is reached for clarity and the way forward needed without further consultations. Ethics po licy for the purchasing department: Personal integrity and professionalism – each and every individual who will be involved in the supply chain should be honest, have due diligence and be caring. Respects should be portrayed towards the clientele as well as to their colleagues. The entire group should maintain confidentiality in their work. Information shared to the public should not be outside the context that is allowed by the hospital management. Accountability and transparency –

Influence of European Enlightenment on modern schooling Essay

Influence of European Enlightenment on modern schooling - Essay Example It also aimed to reform the society by using reasoning and understanding of the phenomena’s by using scientific knowledge. It aligned majority of the thinkers on the lines of reason and understanding during the 17th and 18th century. It was also referred to as an ‘Age of Reason’ by Thomas Paine (Hackett 1992). It is still believed by many that the basis of modern concepts and thoughts lie in the age of Enlightenment. Science, skepticism and intellectual understanding was promoted during this era as opposed to the superstitious thinking and intolerance by church and state (Wilson 2004). Origin of Age of Enlightenment The Era of Enlightenment was sparked by the great philosophers and thinkers of that time. Baruch Spinoza (1632-1677),Pierre Bayle (1647-1706),physicist Issac Newton (1643-1727) and Philosophers Voltaire were the major proponents in originating the Enlightenment movement (Casey 2008). The revolutionary leaders of the Enlightenment movement hailed themse lves as the courageous elites. They claimed to take the world out of the dark period of doubtful traditions and ecclesiastical tyranny due to which the historical wars took place. Education in the Age of Enlightenment The basic purpose of the movement of Enlightenment was to spread scientific knowledge and reasoning among masses and to take people out of the ignorance in which they were plunged in during the Middle Ages.The role of the educational system was very important in spreading the ideas and concepts of Enlightenment among the people. Continuous development took place in the educational system in Europe throughout the Enlightenment period and the French Revolution. The educational development increased and flourished rapidly during the Enlightenment period. Educational history prior to Enlightenment Period Before the period of Enlightenment, religious dogmatic believes and superstitious thinking was given value. The education was considered the sole right of males who belong ed to the upper stratus of the society such as nobles, mercantile and professional class. With the spread of the scientific revolution traditional religious and superficial beliefs gave way to scientific thinking and reasoning. Novel and revolutionary scientific ideas were proposed by the philosophers such as John Locke proposed that sensation and reflection plays a part in obtaining knowledge. Locke later developed a theory which was based on the same idea that every human being are equal in the capacity of sensation detection and that education should be made public and reachable by all classes of the society. The roots of Pedagogy as science, also has its roots in the in the Age of Enlightenment. The education was considered a basic tool by the philosophers and thinkers of that time to fight against ignorance and superstition. It was considered a way to achieve an open-minded and egalitarian society (Farzaneh 2009). They fought against censorship and worked towards the practice o f free speech. They wanted Declarations of Human rights and an easy and free access to education for all people. Spread and growth of Education system The education before the Age of Enlightenment was considered the divine right of only rich and noble upper class of the society. During the 18th and 17th century there was a significant

SYNTHESIS MATRIX about the dangers of smoking Assignment

SYNTHESIS MATRIX about the dangers of smoking - Assignment Example Preventive Medicine, 52 (6), 428-433. Shahid, K. & Elahi, R. (October 19, 2011). Effect of Smoking on Total Serum Cholesterol Level: An investigation of the association between Smoking and Total Serum Cholesterol level from District Peshawar, Pakistan Paperback. United Kingdom: LAP LAMBERT Academic Publishing. The researcher find that some company do not associate with smoker due to the issue of insurance and the nature of the insurance they provide to their worker has a certain limit of money to be provided, higher than for that person suffering from smoking problems The researchers figured out that those children whose mothers used to smoke at the time of pregnancy experienced the issue of shorter height as well as smaller circumference of the head and other abnormalities for as long as 4 years since the time they were born. The researchers figured that a pregnant woman uses a lot of energy during pregnant period and hence smoking dehydrates the body, leading to abnormal functioning of the body tissue and hence affecting pregnancy at

English 311 Essay Example | Topics and Well Written Essays - 2250 words

English 311 - Essay Example There is a wide body of knowledge that addresses various aspects of the issue including causation, prevalence, effects and treatment. Thus, there would be no need for primary research. Alzheimer's disease has for long been associated with old age, particularly age 65 and above. However, it has also been reported to affect teenagers. It affects those with family histories of the disease and those people with diabetes mellitus, elevated levels of plasma homocysteine, cardiovascular diseases, depression, low educational achievement, lack of social interaction, lack of intellectual activity, lack of leisure activities and excessive response to stress. The ethical consideration of care dictates the standards of care that should be given to the people with whom the caregiver has concrete relationships. Alzheimer's disease affects people closely related to the caregiver and should therefore be accorded the deserved care. The following is the definition of Alzheimer's disease using cause-eff ect organizational pattern: Causes of Alzheimer's disease Biological factors Environmental factors Psychological factors Effects of Alzheimer's disease Negative behavioral changes Negative health effects Death Use of medicinal therapy and psychotherapy for treatment As noted by Geldmacher (2012), if Alzheimer's disease is not treated or treated in time, the plaques and tangles spread in the brain leading to death. Therefore, Alzheimer's disease is a dementia that causes problems in memory, behavior and thinking. Paper 2: Alzheimer’s Disease 1. What is Alzheimer’s Disease? Dementia is a terminology used in describing various kinds of brain disorders which progressively result in the loss of brain function. People affected by dementia particularly suffer from the problem of short-memory. Thus, such people consistently forget what they have just done but clearly recall what happened several years back. They typically lose the sense of place and time. Furthermore, they fac e challenges finding words and find it increasingly difficult to do new things or learn new information. With the passage of time, these people would need to be assisted in doing their daily activities such as eating, dressing and washing. Ultimately, they could become incontinent and uncommunicative. Dementias would often last for many years, even 20, and would usually not be the actual cause of death. There are more than 100 varied types of dementia (Alzheimer’s Association, 2013). The most commonly occurring type of dementia is Alzheimer’s disease. According to Alzheimer’s Association (2013), Alzheimer’s disease accounts for about 50% of all dementia cases, while Geldmacher (2012) further indicates that if this is combined with the clinical diagnosis of its occurrence with other diseases, it would account for 90%. Hence, it is common to find people referring to the disease as dementia. More than 5 million people in the US suffer from the disease, causi ng a financial burden of about $ 170 billion every year caring for these patients. By the year 2050, the number of those affected in the US could rise up to 13 million, the growth largely attributed to the growth in the number of the aging population. Alzheimer’s disease is therefore a type of dementia known to cause problems in memory, behavior and thinking. It got its name after a German neurologist, Dr. Alois Alzheimer (1864 –

Its an Argument-Source Paper on American Social Problems... My topic Research Proposal

Its an Argument-Source Paper on American Social Problems... My topic is Alcoholism - Research Proposal Example It is not only the media to blame for the radical directional change; the government has contributed to this course overwhelmingly by failing to enact stiffer laws to control alcohol consumption. By failing to launch massive anti-alcoholism campaigns, the government and the media have failed many families and individuals. The effect of alcoholism on families is immeasurable (Mezzasalma). Sander, when describing what became of their family when his father was enslaved by alcoholism says, â€Å""My brother became a rebel, my sister retreated to shyness†¦" (67). He further reiterates that what he considered â€Å"a private grief† was actually, â€Å"a public scourge† (138). As such, alcoholism qualifies to be a social problem that affects all the societal aspects, legal, economic, and political (Oshea 14). Quitting alcohol is a momentous task that requires everyone’s involvement and the government and the media cannot relent (Pittman 18). It is high time that all stakeholders should stand to be counted for doing what is right, regardless of the political implication, to fight alcoholism. Alcoholism is a monster that has destroyed many resourceful persons, broken many families, and cost lives and should be fought at all cost. Mezzasalma, Lorena. "Characteristics of Alcoholics Attending Clubs of Alcoholics in Treatmentà ¢ in Italy: A National Survey ." Oxford Journals | Medicine | Alcohol and Alcoholism. N.p., 3 Nov. 2011. Web. 3 May

HR as a Strategic partner Essay Example for Free

HR as a Strategic partner Essay Human Resources – the one department that is the most important to a company’s bottom-line is also one that is treated with the least respect across all industries. The general consensus is that the HR Department and the rest of the organization are Strange Bedfellows, when in fact they are Strategic Partners who should blend seamlessly to achieve organizational objectives. But what we see is a single-minded dislike for the HR department by most employees of the organization. The reason for this sorry state of affairs can be traced to several widespread myths regarding the function among employees. Two of the most important ones are as follows: Myth No. 1 – Employees feel that â€Å"The HR function is responsible for making employees happy. They should take care of everything, from providing employees good food to ensuring that the AC’s temperature is just right†. When in reality, an HR manager’s job is not to make employees content; it is to make them competent. In simpler words, HR Managers will not provide you a beanbag at work to recline on, but they will strive to increase your competencies that would hold you in good stead for the rest of your life. And that is all that matters in today’s professional and highly competitive world. Myth No. 2 – â€Å"The HR department comprises of a bunch of people who sit around in their ivory tower and make rules according to their whims and fancies†. While actually, HR as a function not only belongs to HR Managers, but to all managers across the organization. Translated, it means that the HR function is highly inclusive and works in tandem with all departments of the company. The criticality of the HR function can be understood by asking a simple question – What is it that makes any organization a success or a failure? Planning, Strategic decisions, Productivity, Sales figures, etc. , are a few things that instantly come to mind. What we forget to acknowledge is the fact that all these factors are a result of the efforts of the â€Å"people† of the organization. And who ensures that the right kinds of people are positioned in the right jobs in the company? The answer to that one is quite obvious. The HR department performs an array of complex activities – From Manpower Planning to Recruitment, Performance Management to Compensation and Benefits, Training and Development to Career Advancement; all of which aim at Organizational as well as individual employee development. And yet they are accused of being a ‘necessary evil’ and a ‘dark bureaucratic force’ by many. The HR function is Necessary, Yes; is it an evil? No! It is a Force, yes; but Dark and Bureaucratic? No and No! So why is HR misunderstood and mistrusted by so many, especially when the function is a benign one? Honestly, the blame lies partly with the HR managers as well for letting things get out of hand. Somewhere in the trade-off between the various roles that they are expected to play, HRs in general have started placing more importance on the roles of the ‘Admin Expert’ ‘Strategic Partner’ and have foregone the roles of the ‘Change Agent’ and ‘Employee Champion’. While they are performing the former two flawlessly, the latter roles are of great importance as well. And this negligence has resulted in widespread manifestation of disregard for the function. And unless we strike a balance between these paradoxical roles, redefining HR as an EmployeeFriendly function would be an uphill task. That said, let’s take a look what other options we have, as future HR personnel to dispel the feeling of general animosity towards the function? The answer quite simply lies in the basics. As with any other relationship, proper communication is the key to mend damages in professional relationships too. The HR person is every employee’s first point of contact before/ immediately after joining an organization. Right from the induction programs, it is the HR who facilitates the transition of a person from an outsider to a member of the organization. And we need to leverage this power for all its worth right from the word go! We need to establish proper communication channels right from the time of entry of the employee into the organization and ensure that this process of communication is a perpetual process and not an intermittent one. Next of course are the all-encompassing and highly coveted employee engagement programs. Ensuring that the HR department is projected not merely as a facilitator but also as the interface that conducts such engagement activities would ensure that employees have a change in perspective regarding HRs in general. Instead of going about this the tried and tested way, HRs can get creative and use several innovative means to achieve this. From videos depicting ‘a day in the life of an HR’ to shadowing programs (which would give employees a real-time feel of the trials and tribulations of an HR person) the possibilities are endless. And most importantly, as stressed upon earlier in this article, HR is not just about performance appraisals and pay cuts. The function is the backbone of any organization, performing an array of critical activities. HR managers need to convince the employees that they are in fact their allies and not their detractors. The new age HR managers need to remember that each action of theirs reflects on the image of the function as a whole. A slight change in our attitudes would go a long way in changing employee perceptions about our function. We as a team honestly believe that it is not a question of ‘If’ this change would happen; rather it is a question of ‘When’ it would happen. And when this happens, the HR function would assume its rightful position of importance in the Organizational structure.

Theories of Development Essay Example for Free

Theories of Development Essay In my paper, on child development I will discuss three different points of view on cognitive, physical and emotional development. I will write about the three differences and similarities. I will discuss how they have an impact on the way they help in the development of children. I will explain how important child development is in regards to assisting in a child’s potential. I will show the relationship between the developmental domain and the developmental theory. I will focus on all three domains and how they influence each other. Child development is an ongoing process that goes through many complex changes. Children are in a constant state of change from the moment they are born all the way to being a young adult. They develop many characteristics and personalities such as, quantitative changes, and qualitative changes. They area key component in any childs development. There have been many scientific studies on early child development. Many theorists such as, Charles Darwin have studied and devoted a lot of time to the evolution of human development. Scientists, throughout many years have developed three separate domains. In our text, on page nine, they are listed as follows, physical development, cognitive development, and psychosocial development. Physical development is the growth of the body itself. Such as the brain, sensory capacity, and a childs motor skills. Cognitive development is the development of mental ability, learning, memory, language, thinking, moral reasoning, social and emotional growth. Psychosocial development is a pattern of changes in personality, emotions, and social relationships. Scientists categorize all of these different stages of development, but a child is constantly changing. The relationship of these developmental stages all has one common goal, and that is the development of a child into young adulthood. I prefer to use the analogy that a childs development is like a building being constructed. You start with the foundation and over time it grows into a tall, solid structure. As a parent you look at the finished product and you can be proud of the accomplishment. I don’t believe that there is one particular moment in a childs development where you can say it’s definable. It’s an ongoing process or a period of continuous development. Everything in life is a group of sequences and they are usually linked together. There are five major points of a childs development that was written in our texts on page ten. They are the prenatal period. This the period between conception and birth. Then there is the infancy to toddler hood (birth to 3yrs). Then early childhood (ages 3 to 6), middle childhood ages (6 to 11), and finally adolescence, (11 to 20 yrs). This is a very accurate process of the development and changes a child goes through. It really starts to get interesting around the middle childhood ages. This is where social construction comes in. Perceptions are created and assumptions are made by the childs peers. If the family is stable in the home, maintain a loving atmosphere and finances are stable then the child is usually well accepted. This brings me to the topic of the influences that this has on a childs development. Of course every child is an individual and has different family circumstances and environments. A childs maturation is a sequence of behavioral and physical changes. They say girls mature faster than boys. Measuring this process is a topic scientists have debated about for many years. Most believe genetics (heredity) have a lot to do with a childs maturation process. Heredity is basically inborn traits that influence the characteristics of just about every human being from conception to adulthood. Certainly the environment in which a child is brought up in has a considerable affect on a childs development. Socioeconomic status is an area we learned about in our text on pages 13 and 14; The focus was on certain factors such as, a families income, education and occupation. This part of the developmental process can be an advantage or devastating to a childs development. Many people believe if poverty is long lasting it can have a negative affect on a childs behavior and emotional state. In that aspect I agree to a certain extent. I have seen many children come from an impoverished back round and make something of themselves because there family life was strong. Parents can accept their situation or do something to make it better. If the parents are committed to the developmental process of their children it’s a matter of mental strength. Then you have children who come from an upper middle class or rich family and don’t appreciate what they have. Their parents lacked in parental skills and it showed in the way their kids developed. So I tend to think it has a lot to do with the commitment by the parents no matter what environment or socioeconomic status they are in on how their children grow up. I think it is a big mistake to assume or say it’s the norm for a child to develop properly or fail just because of their environment or parents financial status. Sigmund Freud, Erickson, Piaget, and many others have many theories on development. One thing that is perfectly clear is they a have a mutual interaction with each other. I believe the relationship is the evolution. They have many biological perspectives, theories and systems. In order to bring all of these theories together research, whether it is scientific or different perspectives must continue to be done. There are many research methods that are geared toward a childs development. We learned about two such methods and they are quantitative research, and qualitative research. One deals with measurable data and the other interprets nonnumerical data such as feelings and experiences. Research in both of these areas is widely used and provides great insight into a childs development. The difference between the two is that one is done in a controlled environment (quantitative), and the other is conducted in everyday settings, (qualitative). They both have the same common goal, which is to gather information, theorize and examine data. I personally feel like more than one mind is better. Hence the term collaborative research. This particular way of researching was talked about in our text on page fifty-one. Scientists put all their data into a pool and get different ideas and perspectives. This is a good idea and a good way to analyze and research on a broader scale. While going through this class we discussed the negative or positive affects of child care and if it was key in early childhood development. There seems to be a certain time between the ages of six and eleven where a child really starts to establish social skills. Being around other children and learning to implement their cognitive skills is essential to development. Watching how other kids react in certain situations and their behavior helps in the learning process. Piaget believes there are six stages of cognitive development and most environments a child is in all of these approaches can be implemented. Children use their brains to process information, they watch and store things in their memory for later use, and they learn from being stimulated. Processing and evaluating information is a skill they learn to hone as they continue to develop. Some say that even as an infant babies are born with an innate ability to casually reason. Infancy is a time where many emotions are being developed. Babies smile, frown, cry, laugh, and display certain temperaments. These are basic emotions, but these are the first real signs of development in a neurological sense. Infants show other signs of the way they are feeling from facial expressions motor activity and body language. In our text on pages 219 and 220 Carroll Izard wrote about these basic emotions and self conscious emotions. She and her colleagues believed facial expressions such as showing sadness, joy, fear, and interest went along way in understanding the emotional aspects of an infants development. I know as a parent that basic emotions from an infant are really a key component in understanding a babies needs and wants. Infancy is probably the time when development is a critical element. Infants need to be able to trust their caretaker. They have attachment issues and infants can easily become a little disorientated. They start to develop certain temperaments and it can have a direct impact on a parent or parents. Some of these effects can have long term results and lead to anxiety issues. Infants need to feel secure not only around his or her parents but they need the parents to maintain stability in their environment. Stability is important in the bonding process of an infants development. On page 228 and 229 of our text, stability, according to a study on 15 month old children conducted by (Jacobson Hoffman) stated that secure and less stressed toddlers were more varied and had a larger vocabulary. They also have more positive experiences with peers. On the other side of the coin the less secure toddlers showed more fear, anger, and stress. In a perfect world every parent would like the development of their children to go as smooth as possible and all of the researchers, scientists, and theorists will continue to do the best they can at giving parents the tools and knowledge to do the best they can in helping to develop their children. However, they cannot control the environment, social status, or financial status a child is born in to. Conditions change rapidly not only for children but parents as well. Sometimes there can even be internal problems that can affect the development and the relationships between all three domains of development. Yet, all or most of these potential problems can be fixed with one word and that word is stability. In this world we live in all we can ask for as parents is that our children always continue to grow and develop throughout their lifetime. Conclusion Conception all the way to adulthood is a period of great learning and development. Development is a never ending process. We are born, go through life, and then we die. It’s that simple. Life is a series of developments that never truly ends. It starts from infancy to early adolescence. Every stage is a journey, a learning experience, and a series of developments in the maturation of children. Developmental domains and developmental theories help scientists answer many questions in the development of children. As long as we keep making babies we will give theorists and scientists many more things to research and debate on, and as parents we can continue to help develop our children.

Properties of Poly(B-amino Ester)s

Properties of Poly(B-amino Ester)s The poly(b-amino ester)s, a class of biodegradable cationic polymers, were firstly  prepared by Chiellini in 198340. These polymers were based on poly(amidoamine)s  developed in 1970 by Ferruti41, that contain tertiary amines in their backbones and  can be synthesized by a simple Michael addition reaction of bifunctional amines  and bisacrylamides. However, the interest over the use of poly(b-amino ester)s rised  significantly after its use as transfection reagent at Langer Lab in 200042. The development  of poly(b-amino ester)s emerged by the need to develop a cationic polymer  for gene delivery with high transfection efficiency and long-term biocompatibility  including hydrolyzable moieties easily degradable into non-toxic small molecule  byproducts. The synthesis of this polymer can easily be accomplished: without  necessity of independent preparation of specialized monomers; the use of stoichiometric  amounts of expensive coupling reagents, or amine protecti on strategies prior  to polymerization42. The main general objective of the work of mentioned research  group was to develop a polymer-based non-viral vector more efficient and less cytotoxic  than other cationic polymers used at that time for this purpose (such as,  polyethylenimine (PEI) or poly(L-lysine) (PLL)). In fact, poly(b-amino ester) approach exhibited a particularly attractive basis for  the development of new polymer-based transfection vectors for several reasons: the  polymers contain the required amines (positive charges to complex genetic material);  readily degradable linkages (by hydrolysis of ester bonds in the polymer backbones  may increase the biodegradability and biocompatibility); and multiple analogues  could be synthesized directly from compounds commercially available (easy and inexpensive  synthesis) allowing to tune polymer properties (like buffering capacity)42. Besides being used as transfection vector, PbAEs has been also applied in others  biomedical areas, such as delivery systems for drugs43;44 or proteins45;46, magnetic  resonance imaging agents47;48, or as scaffold for tissue engineering49;50. Synthesis and main physicochemical properties of poly(b-amino ester)s The poly(b-amino ester)s are easily synthesized by the conjugate addition of a primary  amine or bis(secondary amine) and a diacrylate, in a one-step reaction without  any side product that need be removed through further purification steps. It can be  prepared without solvents, catalysts, or complex protecting group strategies42;51. Depending on the ratio of monomers during the synthesis, poly(b-amino ester)s  can be tailored to have either amine- or diacrylate-terminated chains. An excess of  either diacrylate or amine monomer results in a prevalence of acrylate- or amineterminated  poly(b-amino ester)s, respectively52;53. The synthesis is performed either neat (solvent free) or in anhydrous organic  solvents to mitigate hydrolytic degradation during synthesis42;54. Normally, experiments  using solvents occur at lower temperature and over long periods of time  compared to solvent-free formulations. Table 1.3 summarizes the main reactions for  the synthesis of PbAE and the obtained properties such as molecular weight, polydispersity  index (à ), solvent solubility or yield. The most common solvents used are dimethylsulfoxide (DMSO), chloroform  (CHCl3), or dichloromethane (CH2Cl2)57. However, others solvents have also been  used, such as methanol, N,N-dimethylformamide (DMF) or N,N-dimethylacetamide  (DMA)59;61–63. The solvent used has influence on the final molecular weight of the  PbAE. For example, the use of CH2Cl2 typically yields higher molecular weight  polymer compared to THF42. On the other hand, solvent-free polymerizations maximize monomer concentrations,  thus favoring the intermolecular addition over intramolecular cyclization reaction64. The absence of solvent also allows rising temperature resulting in a higher  reaction rate and a lower viscosity of the reacting mixture, assisting to compensate  the higher viscosity found on the solvent-free systems. The combination between  increased monomer concentration and reaction temperature resulting in a reduction  in the reaction time64. The solvent-free reactions also allows the generation of higher  molecular weight polymers, besides increasing the reaction rate and obviating the  solvent removal step53;64. After polymerization, PbAE can be precipitated, normally in cold diethyl ether,  hexane42, ether65 or ethyl ether58 and/or then dried under vacuum57;65. Frequently, PbAEs are immediately used or stored in the cold conditions (4 _C52;66;67, 0 _C62, or  -20 _C68–70). Some PbAEs should be also kept airproof due to its strong moisture  absorption ability and easy degradation71. Concerning to the biodegradation and biocompatibility, PbAEs have been shown  generally to possess low cytotoxicity and good biocompatibility42;52;61;55;72. Different  studies have suggested that PbAEs are significantly less toxic than currently available  cationic polymers, such as, PEI and PLL51;64. Nevertheless, the increase of the  number of carbons in the backbone or side chain is associated to the increase of the  cytotoxicity73. PbAE degrade under physiological conditions via hydrolysis of their  backbone ester bonds to yield small molecular weight b-amino acids biologically  inert derivatives42;51;55;74. Some results revealed that the degradation rate of poly(b  amino ester)s was highly dependent on the hydrophilicity of the polymer, i.e., the  more hydrophilic the polymer is, the faster the degradation occurs75;76. In Table 1.4 are summarized the main characteristic of PbAEs which make them  a promising polymeric non-viral vector for gene delivery. Combinatorial libraries a fast and efficient way to evaluate different poly(bamino ester)s A fast and efficient way to study the relationships between structure and function  in particular material that could be prepared with different reagents is using combinatorial  libraries. Due to promising preliminar results of PbAEs as non-viral vectors,  Langer research group reported a parallel approach for the synthesis of hundreds of  PbAEs with different structures and the application of these libraries to a rapid and  high throughput identification of new transfection reagents and structure-function trends. For this purpose, major contributions have been reported52;53;57;66;67;72;75;77;78  not only exploring the possible structure/function relationships, but also imposing  an assortment of monomers (amines were denoted by numbers and acrylates by latin  alphabet letters) used in order to facilitate cataloging of different PbAEs (Table 1.5  and Tables A.1 and A.2 (Appendix A)). The first initial library screening was synthesized in 2001 by Lynn51. 140 Different  PbAEs from 7 diacrylates and 20 amines were prepared with molecular weights  between 2,000 and 50,000 g.mol-1. From this, polymers C93 (Mw = 3180 g.mol-1) and  G28 (Mw = 9170 g.mol-1) revealing transfection levels 4-8 times higher than control  experiments employing PEI. At same time, it was observed that for transfection efficiency,  high molecular weight was not an important parameter. This work was then  completed in 2003 by Akinc57, where biophysical properties and the ability of each  polymer/DNA complex to overcome important cellular barriers to gene deliver were investigated. As previous experiments, complexes formed from polymers C93 and  G28, revealed higher levels of internalization compared to †naked† DNA, displaying  18- and 32-fold more internalization, respectively. In contrast, the majority of the  polyplexes were found to be uptake-limited. Regarding d iameter and zeta potential,  out of 10 polymer/DNA complexes with the highest internalization rates, all  had diameters lower than 250 nm and 9 had positive zeta potentials. By measuring  the pH environment of delivered DNA through fluorescence-based flow cytometry  protocol using plasmid DNA covalently labeled with fluorescein (pH sensitive) and  Cy5 (pH insensitive) it was possible to investigate the lysosomal trafficking of the  polyplexes. The results demonstrated that complexes based on polymers C93 and  G28 were found to have near neutral pH measurements, indicating that they were  able to avoid acidic lysosomal trafficking. In the same year, Akinc64 studied the  effect of polymer molecular weight, polymer chain end-group, and polymer/DNA  ratios on in vitro gene delivery. For this purpose, 12 different structures were synthesized  based only in two different PbAE (C28 prepared from 1,4-butanediol diacrylate  and 1-aminobutanol and E28 prepared from 1,6 -hexanediol diacrylate and  1-aminobutanol) (Figure 1.6.) These structures were synthesized by varying amine/diacrylate stoichiometric ratios, resulting in PbAEs with either acrylate or amine end-groups and with molecular  weights ranging from 3,350 to 18,000 g.mol-1. Polymers were then tested, using high  throughput methods, at nine different polymer/DNA ratios between 10/1 (w/w)  and 150/1 (w/w). Concerning terminal groups, it was found that amino-terminated  polymers transfected cells more effectively than acrylate-terminated polymers. In  contrast, none of the acrylate terminated PbAEs mediated appreciable levels of  transfection activity under any of the assessed conditions. These findings suggest that end-chains of PbAE have crucial importance in transfection activity. Concerning  molecular weight effect, highest levels of transfection occurred using the higher  molecular weight samples of both amine-terminated C28 (Mw _13100 g.mol-1 and  E28 (Mw _13400 g.mol-1). Regarding the optimal polymer/DNA ratios for these   polymers, it was observed a markedly difference, 150/1 (w/w) for C28 and 30/1 for  E28. These results highlighted the importance of polymer molecular weight, polymer/DNA ratio, and the chain end-groups in gene transfection activity. Moreover, it  has found the fact that two similar polymer structures, differing only by two carbons  in the repeating unit, have different optimal transfection parameters emphasizing  the usefulness of library screening to perform these optimizations for each unique  polymer structure. Meanwhile, in 2003, Anderson52 described, for the first time,  a high-throughput and semi-automated methodology using fluid-handling systems  for the synthesis and screening of a library of PbAEs to be used as gene carrier. A crucial feature of these methods was that all process of synthesis, storage, and  cell-based assays were performed without removing solvent (DMSO). By using these  methods, it was possible to synthesize a library of 2350 structurally unique, degradable  and cationic polymers in a single day and then test those as transfection reagent  at a rate of _1000 per day. Among PbAEs tested, it was identified 46 polymers  that transfect in COS-7 as good as or better than PEI. The common characteristic  among them was the use of a hydrophobic diacrylate monomer. Moreover, in the  hit structures mono- or dialcohol side groups and linear, bis(secondary amines) are  over represented. From data obtained from this library, Anderson67, in 2004, continued  his study developing a new polymer library of >500 PbAE using monomers  that led higher transfection efficiency in the previous studies and optimizing their  polymerization conditions. The top performing polyplexes were asses sed by using  an in vitro high-throughput transfection efficiency and cytotoxicity assays at different N/P ratios. As previously observed, the most promising polymers are based on  hydrophobic acrylates and amines with alcohol groups. Among those, C32 stood  out due to higher transfection activity with no associated cytotoxicity. The efficiency  to deliver DNA was evaluated in mice after intra-tumoral (i.t.) and intra-muscular  (i.m.) injection. The results revealed important differences. While by i.t injection  C32 delivered DNA 4-fold better than jetPEI R , a commercial polymeric non-viral  vector, by i.m. administration transfection was rarely observed. C32 was then assessed  for DNA construct encoding the DT-A (DT-A DNA) deliver to cells in culture  and to xenografts derived from androgen-sensitive human prostate adenocarcinoma  cells (LNCaP). Results showed that DT-A DNA was successfully delivered and the  protein expressed in tumor cells in culture. In hu man xenografts, the growth was  suppressed in 40% of treated tumors. The fact of C32 is non-toxic and it is able to  transfect efficiently tumors locally and transfects healthy muscle poorly turned it as  a promising carrier for the local treatment of cancer. From here, a panoply of results based in PbAE combinatorial library appeared. In  2005, Anderson53, prepared a new library of 486 second-generation PbAE based on  polymers with 70 different primary structures and with different molecular weights. These 70 polymers were synthesized using monomers previously identified as common  to effective gene delivery polymers. This library was then characterized by  molecular weight of polymers, particle size, surface charge, optimal polymer/DNA  ratio and transfection efficiency in COS-7 of polymer/DNA complexes. Results  showed that from 70 polymers with primary structures, 20 possess transfection activities  as good as or better than Lipofectamine R 2000, one of the most effective commercially  available lipid reagents. Results also revealed that, in general, the most  effective polymers/DNA complexes had In 2006, Green79, synthesized, on a larger scale and at a range of molecular  weights, the top 486 of 2350 PbAEs previously assessed52 and studied their ability to  deliver DNA. These PbAEs were tested, firstly, on the basis of transfection efficacy in  COS-7 cells in serum-free conditions, and then, the 11 of the best-performing PbAEs  structures were further analyzed. The transfection conditions were optimized in human  umbilical vein endothelial cells (HUVECs) in the presence of serum. In this  study, the influence of the factors like polymer structure and molecular weight, and  biophysical properties of the polyplexes (such as, particle size, zeta potential, and  particle stability throughout time) were studied. The results showed that many of  the polyplexes formed have identical biophysical properties in the presence of buffer,  but, when in the presence of serum proteins their biophysical properties changed differentially,  influencing the transfection ac tivity. Concerning to the size, the results  showed that in spite of all vectors condensed DNA into small particles below 150 nm  in buffer, only a few, such as C32, JJ32 and E28, formed small (_200 nm) and stable  particles in serum. C32, JJ32 and E28 revealed also high transfection activity both  in the absence of serum in COS-7 cell line as in the presence of serum in HUVEC  cell line. Moreover, C32 transfected HUVECs in the presence of serum significantly  higher than jetPEI R and Lipofectamine R 2000, the two top commercially available  transfection reagents. The 3 mentioned PbAEs share a nearly identical structure. The acrylate monomers of these polymers, C, JJ, and E, differ by only their carbon  chain lengths (4, 5, and 6 carbons, respectively). Similarly, amines 20, 28, and 32  differ also by only the length of their carbon chain (3, 4, and 5 carbons, respectively). For example, polymers prepared with the same acrylate monomer (C) in which itwas increased the length of the carbons chain of the amine monomer resulted in  an increased transfection efficacy (C32 (5 carbons) > C28 (4 carbons) > C20 (3 carbons))  of these polymers-based polyplexes. Interestingly, this study reinforced C32  as the lead PbAE vector and revealed other potential two, JJ28 and E28, which previously  showedto be poor vectors. On the other hand, C28 and U28, previously  recognized as an efficient transfection reagent, were found to transfect inefficiently  HUVEC in serum. By constructing a new library of end-modified PbAE, the research  was continued78 in order to understand the structure-function relationship  of terminal modification of PbAE in transfection activity. For this purpose, it was  used twelve different amine capping reagents to end-modify C32, D60 and C20. The  choice of these 3 PbAEs was based in their transfection activity: C32, the most effective; D60, an effective transfection reagent with a significantly different structure  from that of C32; and, C20, a poor transfection reagent but with similar structure  to C32 differing only in the length of the amine monomer. The results showed  that some PbAEs-based vectors (C32-103 and C32-117) were able to deliver DNA by  approximately two orders of magnitude higher than unmodified C32, PEI (25,000  g.mol-1) or Lipofectamine R2000, and, at levels comparable to adenovirus at a reasonably  high level of infectivity (multiplicity of infection = 100). Once again, it was  demonstrated that small structural changes influence greatly gene delivery, from biophysical  properties (such as, DNA binding affinity, particle size, intracellular DNA  uptake) until final protein expression. From these 3 polymers assessed, C20 was the  one who transfected cells much less effectively, although it has seen a remarkably  improvement with end-modifications. As expected, C 32-based polyplexes, based on  C32-103 and C32-117, revealed the higher transfection efficiency enhancing cellular  DNA uptake up to five-fold compared to unmodified C32. Interestingly, and in a  general way, terminal modifications of C32 with primary alkyl diamines were more  effective than those with PEG spacers, revealing that a degree of hydrophobicity at  the chain ends is an added value for these polymers. Another interesting fact in terminal  modification of C32 was that at least a three carbon spacer between terminal  amines is necessary to obtain an efficient gene delivery. For example, results showed  that C32-103 transfection efficiency is 130- and 300-fold higher than C32-102 on the  COS-7 and HepG2 cell lines, respectively. As the molecular weight was the same,  this result demonstrated the critical role of the chain ends in transfection activity. In order to better understand the role of the chain ends in transfection efficiency  a new library of end-modified C32 was synthesized by Zugates80 in 2007 using 37  different amine molecules to end-modify the PbAE. In a general way, it was observed  that polymers end-capped with hydrophilic amine end groups containing  hydroxyls or additional amines led to higher transfection efficiency. On the other  hand, terminal-modifications with hydrophobic amines containing alkyl chains or  aromatic rings proved to be much less effective. Concerning to cytotoxicity, terminal  modification with primary monoamine reagents (independently of functional group  extending from the amine, such as aromatic, alkyl, hydroxyl, secondary and tertiary

A Comparative Study of Evolution and Religion in Education in the United States and China :: Compare Contrast Religious Essays

A Comparative Study of Evolution and Religion in Education in the United States and China Buddhism does not believe in a creator god. It accepts modern ideas about the universe. Hinduism believes that the universe existed first, and then the divine spirit awoke within it and seeded itself and formed Brahma, who is the God. Hinduism, similar to Buddhism, has an evolutionary perspective of life. Both religions accept Darwin’s evolution theory. Islam, Christianity and Judaism all share the same Mesopotamian mythologies (http://www.bbc.co.uk/schools/gcsebitesize/sosteacher/re/37690.shtml). Over half of the world’s population believes in these religions. They believe the world was created by God in six days, which was recorded in the first chapter of Genesis of the Bible. God created the heaven and earth in the beginning and He created day and night on the first day. Then He separated water from the sky on the second day. On the third day God created vegetation, and on the fourth day He created the Sun, the moon and stars to govern day and night. On the fifth day, God created living creatures that live in the water and fly in the sky. One the sixth day, God made the land to produce living creatures on land, and He said â€Å"let us make man in our image, in our likeness, and let them rule over the fish of the sea and the birds of the air, over the livestock, over all the earth and overall the creatures that move along the ground.† God created man in his own image, and He told man to be fruitful and multiply. On the seventh day, God rested from all the creation he had done. What is evolution? The Merriam-Webster Dictionary has many definition of the term â€Å"evolution† (http://www.m-w.com/). The one definition that this paper is mainly referring to is as follows: â€Å"a theory that the various types of animals and plants have their origin in other preexisting types and that the distinguishable differences are due to modifications in successive generations.† Evolution is tightly associated with Charles Darwin. The British naturalist was under the influence of Charles Lyell, who argued in his book Principles of Geology that the Earth was shaped by accumulative, gradual changes instead of great catastrophes. Darwin traveled with the Beagle around the world and collected specimen. He published his book Origin of species in 1859. The two major themes or Darwin’s theory are â€Å"Descent with Modification† and â€Å"Natural selection and adaptation. A Comparative Study of Evolution and Religion in Education in the United States and China :: Compare Contrast Religious Essays A Comparative Study of Evolution and Religion in Education in the United States and China Buddhism does not believe in a creator god. It accepts modern ideas about the universe. Hinduism believes that the universe existed first, and then the divine spirit awoke within it and seeded itself and formed Brahma, who is the God. Hinduism, similar to Buddhism, has an evolutionary perspective of life. Both religions accept Darwin’s evolution theory. Islam, Christianity and Judaism all share the same Mesopotamian mythologies (http://www.bbc.co.uk/schools/gcsebitesize/sosteacher/re/37690.shtml). Over half of the world’s population believes in these religions. They believe the world was created by God in six days, which was recorded in the first chapter of Genesis of the Bible. God created the heaven and earth in the beginning and He created day and night on the first day. Then He separated water from the sky on the second day. On the third day God created vegetation, and on the fourth day He created the Sun, the moon and stars to govern day and night. On the fifth day, God created living creatures that live in the water and fly in the sky. One the sixth day, God made the land to produce living creatures on land, and He said â€Å"let us make man in our image, in our likeness, and let them rule over the fish of the sea and the birds of the air, over the livestock, over all the earth and overall the creatures that move along the ground.† God created man in his own image, and He told man to be fruitful and multiply. On the seventh day, God rested from all the creation he had done. What is evolution? The Merriam-Webster Dictionary has many definition of the term â€Å"evolution† (http://www.m-w.com/). The one definition that this paper is mainly referring to is as follows: â€Å"a theory that the various types of animals and plants have their origin in other preexisting types and that the distinguishable differences are due to modifications in successive generations.† Evolution is tightly associated with Charles Darwin. The British naturalist was under the influence of Charles Lyell, who argued in his book Principles of Geology that the Earth was shaped by accumulative, gradual changes instead of great catastrophes. Darwin traveled with the Beagle around the world and collected specimen. He published his book Origin of species in 1859. The two major themes or Darwin’s theory are â€Å"Descent with Modification† and â€Å"Natural selection and adaptation.

The Public Choice Essays -- Education School Essays

The Public Choice For some parents, deciding on a school for their children can be a difficult decision. Many parents do not spend much time thinking about it; they place their children into the local school designated by where they live. Others attended a private school themselves and found that it was a beneficial experience and therefore want the same for their kids. But which is better: private schools or public schools? While there are many advantages and disadvantages in each (nothing is going to be absolutely perfect), we are going to focus on the benefits of an education in the public school system, or in other words, schools funded by the government that are for anyone to attend. An accurate definition found in the Encyclopedia of American Education (1996) states: â€Å"Any elementary or secondary school under control of elected or appointed civil authority, supported entirely by public tax monies, and, with few exceptions, open to all students in a designated district, free of any tuition charges.† (780) These include elementary, secondary schools and vocational schools. Public schools are a good choice in education because they provide a wide variety of subjects to study, are diverse in their student body, available to everyone, yet can sometimes be misunderstood. Imagine sitting in a class, completely bored out of your mind. This is not difficult considering everyone has taken a class like this somewhere along the road of their education. Not every class can be exciting and we should know that. Now imagine every class is of this level, with no â€Å"break†, or elective, classes incorporated into your day. Although this may not apply to all private schools, there are many that focus on specific topics. So even though the... ...des. Students who do well in a public school setting tend to feel better about themselves. They succeed because they want to, not because someone else forced them to. Whether someone prefers a public school or a private school, it all depends on the person. Unfortunately, not everyone is able to appreciate all that public schools have to offer because they get their vision blurred by all the benefits of private schools. The only thing holding them back may be cost. If these people would just take some time to find that there are just as many wonderful things about the schools our governments provide, they may feel more confident in their choice. Those never exposed to anything but private education miss out on the diversity among students, extra vocational and extracurricular classes, and may even continue to not understand all that public schools have to offer.

Organ Donation :: essays papers

Organ Donation In March of 1999, I was given a gift from a person I never knew; a person I’ll never get to know. This gift cost the person who gave it to me, no money, but it was the most valuable gift I’ll ever receive. The gift was a piece of life from another person. At the age of twenty-four, I broke my hip. After three unsuccessful surgical attempts to heal it, my doctors performed a total hip replacement. The top four inches of my femur were sawed off, and the inside of my bone was hollowed out. A steel rod, nine inches long, was â€Å"pressed fit† into my bone. I was on crutches for over a year, but I really believed I would be able to walk on my own again. Less than one year after the surgery, I was back on crutches and in terrible pain. I had developed stress fractures in several places along my femur. For nearly one year I walked only when it was necessary and ate painkillers as though they were candy. Finally, my doctors decided to try something new. On March 9, 1999, my doctors took a rib bone, donated from a cadaver, split it in half, and wired it around my broken femur. Less than two months later, I was off crutches and walking normally for the first time in almost five years. I could actually enjoy life. I was lucky. I wasn’t going to die if I had no donor, donated bone is easier to acquire that a heart, lung or kidney. Other people are not as lucky. Patients waiting for one of those life-sustaining organs must rely on the generosity of others, and the misfortune of that generous person. Someone must die, in order for that person to live. No one likes to talk about death, but let’s face it, we all die. Dying is a part of life. Many people don’t talk about organ donation because it involves talking about death. But, what if, from our death, we could give another person a chance to live, or merely improve the quality of his or her life? As of September 1999, over 65,000 people wait, with their name on a list, for a life saving organ. Only a fraction of those will live long enough to receive that organ.

Basic Business Concepts

Business: It is the act of manufacturing, producing or buying and selling of goods and services whose aim is to make profit. A product may be defined as the output which could be in terms of services or goods within the normal business transaction.Generally, the fundamental goal of business if to make profit through optimization of its costs and revenue. However, business organizations are the entities that are ideally driven by the profit motive. Non profit making organizations does not aim atmaking profit. 2. Every business activity involves various participants/stakeholders.They include producers/manufactures, distributors, consumers and legal entities (John, 2006). Producers/manufacturers make the goods and services for use in the business process. Consumers are involved in using the products that are manufactured and produced in business processes. Distributors create channels of goods and service transfers from the manufactures to the consumers. Legal entities/government create s the legal layout of conduct between the other three participants. Studying business in the today’s American society is ideally an important aspect that provides information on the aspects that ensure strong business functionality.It provides the most rational knowledge that would help to succeed in any business process. However, business process is affected by various aspects such as international forces of demand and supply, income of the consumers, government regulation, availability of raw material, and economic systems (John, 2006). 3. Economics is the study of fundamentals of incorporating the scarce resources in processes that yield the highest benefit to the community. There are various economic systems which include; Traditional economy is that characterized by techniques and models based on social foundations.It involves resource inheritance and brings a passive sense of togetherness and community. It has low technology and no competition. Command economy is that w hich is controlled and planned by the central government. It is shaped by the will of the government. The means of economic production are owed by the people. It can be found in Vietnam. Market economy is controlled by forces of demand and supply. Government rarely fixes the prices. Private corporations govern the control of distribution and exchange. Example is United Kingdom.Mixed economy compliments both market and command economy. There are both the hands of government and corporations. It is governed by high freedom in its activities. An example is in US (John, 2006). 4. Supply is the total amount of goods and services offered in the market by the produces. Demand id the total quantity of goods and services required for consumption in the market. Price is the single cost paid for a unit of goods or services. Competition refers to the interactive process between suppliers and consumers within the market to yield an equilibrium quantity and price.In America, the competitive natur e of the market ensures the interaction between the quantities of goods and services supplied and demanded to produce an equilibrium price and quantity for the supplies and demands levels (John, 2006). 5. There are four types of competitions. Perfect competition is where we have many suppliers and consumers who interact cohesively with one another to yield an equilibrium quantity and price. Example is the hotel industry. Monopoly competition is where there is one supplier against many consumers. He/she controls the pricing of the goods and services.Example is the development in new communication technology. Duopoly competition is the competition between two suppliers. It may include the development in mobile phone technology between two manufactures. Oligopoly competition is where there are few sellers and many buyers. It may include the market of electronics. 6. The government uses various attributes to measure the state of economic development. They include; Inflation: This is the subsequent increase in the price of commodities. GDP: It is the sum total of all goods and services produced within a country within one year.Unemployment: It is the relationship between the workforce that is willing and also able to work and is in the process of finding a job compared to the number that is absorbed in the employment industry. Consumer Price Index: This is relative changes in the prices of consumer goods within the economy. The rate of unemployment is relative to the level of GDP. Higher unemployment implies lower GDP. This is because, there are low levels of income earned by the household and consequently law levels of aggregate demand within the economy. Economic fluctuations are usually desirable in the economic functionality theory.This is ideally because such fluctuations are detrimental in clearing the various markets within the economy. The federal government in America performs the role of ensuring both strong fiscal and monetary policies which ensure a str ong economy (John, 2006). 7. Service economy is the economy endowed with product output that is governed by services rather than goods. In America, service economy refers to the economic domains implied by the supply and demand of services as product outputs. Reference John Robert (2006) Economic Theory: An Introduction. New York, Prentice Hall

Career Goal-Setting Worksheet Essay

1. go under your professional person or line of achievement final stage you created in Week Two establish on the Career Plan mental synthesis Activities results from the My Career Plan assignment. How did the results of the Career enliven Profiler and Career Plan Building action on Competencies contribute to your professional finale development? My career closing has not changed after I did the activity. The results of my career beguile profiler told me what I had already known all told my bearing. My profiler results and career plan goes right along with what Im currently doing in my field of work. It only if helped me to see Im on the right trace of earning my business degree.2. Describe how you will quietus academician expectations and your personal and professional responsibilities. In order to have balance I have to recognize what is important and what is just sucking away my time, energy and attention. apparel clear personal and professional goals and alter my life to include only what is important in helping me reach my goals. purpose the perfect work-life balance is a womb-to-tomb journey. It doesnt happen overnight. It only happens with unplayful effort and constant attention3. How domiciliate understanding the importance of SMART criteria and your career interests and competencies help you move toward your career and academic goals? One academic goal I have created using the SMART is acquire my degree in business management, the origin is this goal has a lot to do with my professional goal. The main goals in my life are academic and professional, for me to get a good career and achieve at opening my Electronics store the academic goal has to be carry outed first to accomplish the professional goal.4. Now that you have posture academic goals and identified your career interests, exempt the relationship between academic goals, skills, and professional

The Behavior Of Human Being Health And Social Care Essay

styluso put downical epitome is a subject piece of bunk the behaviour of charitable being in assorted societal scene. Harmonizing to Merton ( 1957 ) systemo enterical analysis is the logic of scientific mental process. The look is a establishmentatic method of detecting new facts for collateral old facts, their successiveness, interrelatedness, insouciant news report and natural Torahs that curb them.The scientific methodological analysis is a carcass of explicit regulations and processs upon which research is based and against which the claim for perception atomic number 18 evaluated. This subdivision of the survey edifying the ex planation of the survey country, definitions of stuff use methods to accomplish the aims and ingrained parts of the present survey.3.1 Data CollectionThe info is collected by carry oning a subject ara so that those ciphers chamberpot be considered which were non available in the infirmary record and were most of import as the haza rd factors of hepatitis. The fill was conducted in the liver center of the DHQ infirmary Faisalabad during the months of February and March 2009. A questionnaire was do for the form of study and only feasible hazard factors were added in it. During the twain months the skeleton of patients that were interviewed was 262.The factors studied in this study atomic number 18 Age, Gender, Education, Marital Status, Area, Hepatitis Type, Profession, Jaundice History, History of daub Transfusion, History of Surgery, Family History, Smoking, and Diabetes. Most of the factors in this culture lay out be binary and roughly take up to a great extent(prenominal) than deuce somas. Hepatitis fount is resolution shifting which has 3 bods.3.2 Restrictions of DatasIn the outline it was decided to take a complete study on the five types of hepatitis just during the study it was known that hepatitis A is non a life-threatening disease and the patients of this disease atomic number 18 non admitted in the infirmary. In this disease patients thunder mug be both right wing after 1 or 2 look into ups and largely patients do nt cognize that they hold up this disease and with the transition of clip their disease finished without whole side consequence. On the some former(a)wise manus, hepatitis D and E atomic number 18 authentic tout ensembley r ar and really shaky diseases. HDV can hold growing in the strawman of HBV. The patient, who has hepatitis B, can hold hepatitis D save non the some other(a) than that. These be really r atomic number 18 typesetters cases. During my ii months study non a individual patient of hepatitis A, D and E was tack together. Largely flock argon enduring from the hepatitis B and C. So now the subordinate uncertain has collar sets. at that placefore polynomial logisticalalalal arrested evolution a priori history with a pendant covariant retentivity leash classs is make.3.3 Statistical incon sistentsThe word protean is utilise in statistically oriented literature to ask a characteristic or a retention that is come-at-able to mensu identify. When the research worker sums something, he work ups a numerical theoretical account of the phenomenon being bank noted. cadences of a inconstant addition their importee from the fact that thither exists a solely correspondence amidst the charge Numberss and the degrees of the belongings being criterion of m unmatchedyd.In the finding of the allow for statistical analysis for a attached set some of instructions, it is utile to sort variable quantitys by type. One method for sorting variables is by the grade of edification perspicuous in the air they are measured. For illust symmetryn, a research worker can mensurate tallness of people harmonizing to whether the top of their caput exceeds a grade on the wall if yes, they are tall and if no, they are short. On the other manus, the research worker can in add ition mensurate tallness in centimetres or inches. The later(a) technique is a to a greater extent sophisticated manner of mensurating tallness. As a scientific subject progresss, measurings of the variables with which it deals compose much sophisticated.Assorted efforts fork over been made to formalize variable assortment. A normally recognized system is proposed by Stevens ( 1951 ) . In this system measurings are sort as nominal, ordinal, interval, or ratioality graduated tables. In deducing his sorting, Stevens characterized all(prenominal) of the four types by a displacement that would non alter a measurings smorgasbord.Table 3.1 Steven s Measurement SystemType of MeasurementBasic empirical operationExamplesNominal endeavor of equality of classs.Religion, Race, Eye colour, Gender, and so onOrdinal design of greater than or microscopic(prenominal) than ( ranking ) . evaluation of pupils, Ranking of the BP as low, medium, high etc. sequence intervalDetermination of e quality of differences amid degrees.Temperature etc.RatioDetermination of equality of ratios of degrees.Height, Weight, etc. variable quantity of the survey are of savorless in temper and holding nominal and ordinal type of measuring.3.4 varyings of epitomeSince the chief focal point of this survey is on the association of different hazard factors with the presence of HBV and HCV. Therefore, the somebody in the informations were loosely classified into three conventions. This variety is based on whether an person is a aircraft carrier of HBV, HCV or N wholeness of these. Following table explains this categorization.Table 3.2 salmagundi of PersonsNo.SampleHepatitisPercentageI100No38.2 ii19HBV7.3 iii143HCV54.6Entire262 1003.4.1 Categorization of Predictor VariablesNominal type variables and cryptography isSexual activity Male 1 Female 2Area Urban 1 Rural 2Marital Status individual 1 Married 2Hepatitis Type No 1 B 2 C 3Profession No1 Farmer2 Factory3 Govt. 4 5 shit KeeperJa undice Yes 1 No 2History Blood Transfusion Yes 1 No 2History Surgery Yes 1 No 2Family History Yes 1 No 2Smoking Yes 1 No 2Diabetess Yes 1 No 2Ordinal type variable and cryptography isAge 11 to 20 1 21 to 30 2 31 to 40 3 41 to 50 4 51 to 60 5Education Primary 1 Middle 2 Metric 3 Fas 4 BA 5 University 63.5 Statistical AnalysisThe discriminate statistical analysis techniques to accomplish the aims of the survey embarrass frequence distribution, per centums and eventuality tabular arraies among the of import variables. In multivariate analysis, comparison of logistical Regression and mis carrel some(prenominal) shoe corners is made.The statistical bundle SPSS was use for the intent of analysis.3.6 Logistic Arrested knowledgeLogistic arrested developing is per centum of statistical theoretical accounts called generalised running(a) theoretical accounts. This wide-eyed crime syndicate of theoretical accounts includes ordinary arrested breeding and analysis of discrepancy, every play good as multivariate statistics such(prenominal) as analysis of covariance and Loglinear arrested cultivation. A massive intervention of generalised additive theoretical accounts is presented in Agresti ( 1996 ) .Logistic arrested ontogenesis analysis surveies the blood among a matt response variable and a determine of in restricted ( informative ) variables. The arrive at logistic arrested increment is oft apply when the pendant variable has only two hold dear. The name nine-fold- throng logistic arrested information ( MGLR ) is normally reserved for the sheath when the response variable has more than two on the whole determine. Multiple- base logistic arrested using is sometimes called polynomial logistic arrested development, polytomous logistic arrested development, polychotomous logistic arrested development, or nominal logistic arrested development. Although the information verbalism is different from that of multiple arrested developments, th e practical usage of the process is comparable.Logistic arrested development competes with discriminant analysis as a method for analysing distinct dependent variables. In fact, the latest esthesis among m some(prenominal) statisticians is that logistic arrested development is more all-mains(prenominal) and superior for most commonwealth of affairss than is discriminant analysis because logistic arrested development does non presume that the explanatory variables are normally distributed while discriminant analysis does. Discriminant analysis can be used exactly in instance of unvarying explanatory variables. Therefore, in cases where the predictor variables are categorical, or a mixture of unremitting and categorical variables, logistic arrested development is preferred.Provided logistic arrested development theoretical account does non affect object trees and is more similar to nonlinear arrested development such as suiting a multinomial to a situated of informations set .3.6.1 The Logit and Logistic TransformationsIn multiple arrested development, a mathematical theoretical account of a set of explanatory variables is used to yell the mean of the dependant variable. In logistic arrested development, a mathematical theoretical account of a set of explanatory variable is used to foretell a transmutation of the dependant variable. This is logit transmutation. Suppose the numerical prizes of 0 and 1 are assigned to the two classs of a binary variable. Often, 0 represents a prejudicial response and a 1 represents a substantiating response. The mean of this variable lead be the residual of positively charged responses. Because of this, we might seek to pattern the kinship between the chance ( proportion ) of a positive response and explanatory variable. If P is the proportion of observations with a response of 1, so 1-p is the chance of a response of 0. The ratio p/ ( 1-p ) is called the odds and the logit is the logarithm of the odds, or that log odds. Mathematically, the logit transmutation is create verbally asThe following tabular array shows the logit for assorted values of P.Table 3.3 Logit for Various Values of PPhosphorusLogit ( P )PhosphorusLogit ( P )0.001-6.9070.9996.9070.010-4.5950.9904.5950.05-2.9440.9502.9440.100-2.1970.9002.1970.200-1.3860.8001.3860.300-0.8470.7000.8470.400-0.4050.6000.4050.5000.000 find that while P ranges between zero point in and ace, the logit scopes between subtraction and plus eternity. Besides note that the zero point logit occurs when P is 0.50.The logistic transmutation is the opposite of the logit transmutation. It is written as3.6.2 The Log Odds TransformationThe difference between two log odds can be used to compare two proportions, such as that of males versus females. Mathematically, this difference is writtenThis difference is frequently referred to as the log odds ratio. The odds ratio is frequently used to compare proportions a violate separates. bank note that the logistic transmutation is closely related to the odds ratio. The contradictory relationship is3.7 The Multinomial Logistic Regression and Logit mock upIn multiple- gathering logistic arrested development, a distinct dependant variable Y holding G al 1 values is a regressed on a set of p independent variables. Y represents a manner of partitioning the population of involvement. For illustration, Y may be presence or absence of a disease, posture after surgery, a matrimonial position. Since the names of these drainage basinrs are arbitrary, refer to them by back-to-back Numberss. Y leave take on the values 1, 2, a , G. permitThe logistic arrested development theoretical account is inclined up by the G equationsHere, is the chance that an single with values is in theme g. That is,Normally ( that is, an intercept is include ) , but this is non necessary. The quantities represent the antecedent chances of group rank. If these anterior chances are assumed equal, so the term beco mes zero and drops out. If the priors are non assumed equal, they change the values of the intercepts in the logistic arrested development equation. The arrested development coefficients for the touch on group set to zero. The pick of the mention group is arbitrary. Normally, it is the largest group or a control group to which the other groups are to be compared. This leaves G-1 logistic arrested development equations in the polynomial logistic arrested development theoretical account.are population arrested development coefficients that are to be estimated from the informations. Their estimations are represented by B s. The represents the unknown parametric quantities, while the B s are their estimations.These equations are additive in the logits of p. However, in foots of the chances, they are nonlinear. The check nonlinear equations areSince =1 because all of its arrested development coefficients are zero.Frequently, all of these theoretical accounts referred to as logistic ar rested development theoretical accounts. However, when the independent variables are coded as ANOVA type theoretical accounts, they are sometimes called logit theoretical accounts. can be interpret as thatThis shows that the last value is the merchandise of its single reasons.3.7.1 work out the Likelihood EquationTo better notation, allowThe likelihood for a specimen of N observations is so given bywhere is mavin if the observation is in group g and zero otherwise.Using the fact that =1, the likeliness, L, is given byMaximal likeliness estimations of are found by pass alonging those values that maximize this log likeliness equation. This is carry out by imageing the partial derived functions and so equates them to zero. The ensuing likeliness equations areFor g = 1, 2, a , G and k = 1, 2, a , p. Actually, since all coefficients are zero for g=1, the scope of g is from 2 to G.Because of the nonlinear nature of the parametric quantities, thither is no closed-form solution to these equations and they moldiness be solved iteratively. The Newton-Raphson method as described in Albert and Harris ( 1987 ) is used to work out these equations. This method narks usage of the information matrix, , which is form from the second partial derived function. The elements of the information matrix are given byThe information matrix is used because the asymptotic covariance matrix is equal to the opposite of the information matrix, i.e.This covariance matrix is used in the computation of sanction intervals for the arrested development coefficients, odds ratios, and predicted chances.3.7.2 Interpretation of Regression CoefficientsThe training of the estimated arrested development coefficients is non lightheaded as compared to that in multiple arrested development. In polynomial logistic arrested development, non merely is the relationship between X and Y nonlinear, but besides, if the dependant variable has more than two alone values, in that location are several arr ested development equations.See the sincere instance of a binary response variable, Y, and one explanatory variable, X. Assume that Y is coded so it takes on the values 0 and 1. In this instance, the logistic arrested development equation isNow consider impact of a social unit addition in X. The logistic arrested development equation becomesWe can insulate the incline by victorious the difference between these two equations. We haveThat is, is the log of the odds at X+1 and X. Removing the logarithm by exponentiating both sides givesThe arrested development coefficient is interpreted as the log of the odds ratio comparing the odds after a one unit addition in X to the original odds. Note that, unlike the multiple arrested developments, the exercise of depends on the shady value of X since the chance values, the P s, give change for different X.3.7.3 Binary autarkic VariableWhen Ten can take on merely two values, say 0 and 1, the above reading becomes even transparentr. Sinc e in that respect are merely two possible values of X, there is a alone reading for given by the log of the odds ratio. In mathematical term, the logical implication of is soTo wholly understand, we must take the logarithm of the odds ratio. It is unspoken to believe in footings of logarithms. However, we can retrieve that the log of one is zero. So a positive value of indicates that the odds of the numerator are big while a negative value indicates that the odds of the denominator are larger.It is fortune easiest to believe in footings of instead than a, because is the odds ratio while is the log of the odds ratio.3.7.4 Multiple Independent VariablesWhen there are multiple independent variables, the reading of from severally one arrested development coefficient more hard, particularly if fundamental interaction footings are included in the theoretical account. In general nevertheless, the arrested development coefficient is interpreted the same as above, except that the cauti on holding all other independent variables changeless must be added. That is, can the values of this independent variable be change magnitude by one without altering any of the other variables. If it can, so the reading is as earlier. If non, so some type of conditional statement must be added that histories for the values of the other variables.3.7.5 Polynomial Dependent VariableWhen the dependant variable has more than two values, there exit be more than one arrested development equation. Infect, the determine of arrested development equation is equal to one less than the figure of categories in dependent variables. This makes reading more hard because there is several arrested development coefficients associated with for all(prenominal) one independent variable. In this instance, perplexity must be interpreted to understand what all(prenominal) arrested development equation is prospect. Once this is understood, reading of each of the k-1 arrested development coefficients for each variable can continue as above.For illustration, dependant variable has three classs A, B and C. Two arrested development equations allow for be generated matching to any two of these index variables. The value that is non used is called the mention class value. As in this instance C is interpreted as mention class, the arrested development equations would beThe two coefficients for in these equations, , give the change in the log odds of A versus C and B versus C for a one unit alteration in, severally.3.7.6 PremisesOn logistic arrested development the animated limitation is that the result should be distinct.One-dimensionality in the logit i.e. the logistic arrested development equation should be additive related with the logit descriptor of the response variable.No outliers liberty of mistakes.No Multicollinearity.3.8 Categorization TreesTo foretell the rank of each category or object in instance of categorical response variable on the footing of one or more predicto r variables categorization trees are used. The flexibleness ofA categorization trees makes them a really dramatic analysis woof, but it can non be said that their usage is suggested to the skip of more conventional techniques. The traditional methods should be preferred, in fact, when the theoretical and distributional premises of these methods are fulfilled. But as an excerpt, or as a technique of last resource when traditional methods fail, A categorization treesA are, in the fancy of many a(prenominal) research workers, unsurpassed.The survey and usage ofA categorization treesA are non prevailing in the Fieldss of chance and statistical theoretical account sensing ( Ripley, 1996 ) , butA categorization treesA are by and large used in employ Fieldss as in medical specialty for diagnosing, figuring machine scientific discipline to measure informations constructions, phytology for categorization, and in psychological science for doing determination theory.A salmagundi tre es eagerly provide themselves to being displayed diagrammatically, functioning to do them easy to construe. Several tree routine algorithmic ruleic rules are available. In this survey three algorithms are used tangle ( Classification and Regression Tree ) , CHAID ( Chi-Square robotic Interaction Detection ) , and call for ( Quick impartial Efficient Statistical Tree ) .3.9 CHAID AlgorithmThe CHAID ( Chi-Square spontaneous Interaction Detection ) algorithm is originally proposed by Kass ( 1980 ) . CHAID algorithm allows multiple carve ups of a client. This algorithm merely accepts nominal or ordinal categorical forecasters. When forecasters are perpetual, they are transformed into ordinal forecasters before utilizing this algorithmIt consists of three stairss meeting, disconnectedting and fish fillet. A tree is pornographic by repeatedly utilizing these three stairss on each pommel get downing organize the ascendant guest.3.9.1. MergingFor each explanatory variable T en, fuse non-significant classs. If X is used to divide the invitee, each concluding class of X will ensue in one kid thickening. Adjusted p-value is besides compute in the confluent measure and this P value is to be used in the measure of ruptureting.If there is merely one class in X, so halt the process and set the correct p-value to be 1.If X has 2 classs, the correct p-value is computed for the incorporate classs by victimization Bonferroni accommodations.Otherwise, paradete the sensible conjure of classs of X ( a sensible elicit of classs for ordinal forecaster is two next classs, and for nominal forecaster is any two classs ) that is least significantly different ( i.e. more similar ) . The most kindred brace is the brace whose ladder statistic gives the highest p-value with regard to the response variable Y.For the brace holding the highest p-value, look into if its p-value is larger than significance-level. If it is larger than significance degree, this brace is co-ordinated into a individual mingled class. Then a new set of classs of that explanatory variable is formed.If the freshly created multiform class consists of three or more original classs, so happen the outstrip binary pick within the compound class for which p-value is the smallest. Make this binary pick if its p-value is non greater than significance degree.The familiarised p-value is computed for the merged classs by using Bonferroni accommodation.Any class holding excessively few observations is merged with the most likewise other class as measured by the largest of the p-value.The adjusted p-value is computed for the merged classs by using Bonferroni accommodation.3.9.2. unconnectedtingThe best bump for each explanatory variable is found in the measure of unifying. The rending measure selects which predictor to be used to outdo split the leaf inspissation. election is accomplished by comparing the adjusted p-value associated with each forecaster. The adjusted p-v alue is obtained in the confluent measure.Choose the independent variable that has minimum adjusted p-value ( i.e. most important ) .If this adjusted p-value is less than or equal to a user-specified alpha-level, split the lymph knob utilizing this forecaster. Else, do non divide and the knob is considered as a entrepot guest.3.9.3. FilletThe stopping measure cheques if the tree turning social occasion should be halt harmonizing to the following fillet regulations.If a client becomes small that is, all instances in a thickener have indistinguishable values of the dependant variable, the boss will non be split.If all instances in a guest have indistinguishable values for each forecaster, the node will non be split.If the current tree profundity reaches the user specified supreme tree reconditeness bound value, the tree turning procedure will halt.If the surface of a node is less than the user-specified nominal node size value, the node will non be split.If the spli t of a node consequences in a kid node whose node size is less than the user-specified minimal kid node size value, baby bird nodes that have excessively few instances ( as compared with this disgrace limit ) will unify with the most similar kid node as measured by the largest of the p-values. However, if the ensuing figure of child nodes is 1, the node will non be split.3.9.4 P-Value Calculation in CHAIDCalculations of ( unadjusted ) p-values in the above algorithms depend on the type of dependent variable.The confluent measure of CHAID sometimes needs the p-value for a brace of X classs, and sometimes needs the p-value for all the classs of X. When the p-value for a brace of X classs is needed, merely portion of informations in the current node is relevant. Let D denote the relevant information. Suppose in D, X has I classs and Y ( if Y is categorical ) has J classs. The p-value computation utilizing informations in D is given below.If the dependant variable Y is nominal categor ical, the vacate guessing of independency of X and Y is tested. To execute the mental test, a eventuality ( or count ) tabular array is formed utilizing categories of Y as columns and classs of the forecaster X as rows. The expected carrell frequences under the void hypothesis are estimated. The ascertained and the expected cell frequences are used to work out the Pearson chi- full-bloodedd statistic or to grave the likeliness ratio statistic. The p-value is computed based on all one of these two statistics.The Pearson s Chi-square statistic and likeliness ratio statistic are, severally,Where is the ascertained cell frequence and is the estimated expected cell frequence, is the amount of ith row, is the amount of jth column and is the expansive sum. The be p-value is given by for Pearson s Chi-square mental test or for likeliness ratio tally, where follows a chi-squared distribution with d.f. ( J-1 ) ( I-1 ) .3.9.5 Bonferroni AdjustmentsThe adjusted p-value is calculated as the p-value times a Bonferroni multiplier factor. The Bonferroni multiplier adjusts for multiple trials.Suppose that a forecaster variable originally has I classs, and it is reduced to r classs after the confluent stairss. The Bonferroni multiplier B is the figure of possible ways that I classs can be merged into R classs. For r=I, B=1. For use the following(prenominal) equation.3.10 QUEST AlgorithmQUEST is proposed by Loh and Shih ( 1997 ) as a Quick, Unbiased, Efficient, Statistical Tree. It is a tree-structured categorization algorithm that yields a binary determination tree. A comparing survey of QUEST and other algorithms was conducted by Lim et Al ( 2000 ) .The QUEST tree turning procedure consists of the resource of a split forecaster, choice of a split point for the selected forecaster, and halting. In QUEST algorithm, univariate splits are considered.3.10.1 select of a discover ForecasterFor each ceaseless forecaster X, execute an ANOVA F trial that trials if all th e different categories of the dependant variable Y have the same mean of X, and cipher the p-value harmonizing to the F statistics. For each categorical forecaster, execute a Pearson s chi-square trial of Y and X s independency, and cipher the p-value harmonizing to the chi-square statistics.Find the forecaster with the smallest p-value and denote it X* .If this smallest p-value is less than I / M, where I ( 0,1 ) is a degree of significance and M is the entire figure of forecaster variables, forecaster X* is selected as the split forecaster for the node. If non, perish to 4.For each uninterrupted forecaster X, compute a Levene s F statistic based on the rank(a) divergence of Ten from its category mean to confirm if the discrepancies of X for different categories of Y are the same, and cipher the p-value for the trial.Find the forecaster with the smallest p-value and denote it as X** .If this smallest p-value is less than I/ ( M + M1 ) , where M1 is the figure of uninterrupted fo recasters, X** is selected as the split forecaster for the node. Otherwise, this node is non split.3.10.1.1 Pearson s Chi-Square TrialSuppose, for node T, there are Classs of dependent variable Yttrium. The Pearson s Chi-Square statistic for a categorical forecaster Ten with classs is given by3.10.2 Choice of the Split PointAt a node, suppose that a forecaster variable Ten has been selected for dividing. The following measure is to make up ones mind the split point. If X is a uninterrupted forecaster variable, a split point vitamin D in the split Xad is to be situated. If X is a nominal categorical forecaster variable, a subset K of the set of all values taken by X in the split XK is to be determined. The algorithm is as follows.If the selected forecaster variable Ten is nominal and with more than two classs ( if X is binary, the split point is clear ) , QUEST foremost transforms it into a uninterrupted variable ( name it I? ) by delegating the largest discriminant co-ordinates to classs of the forecaster. QUEST so applies the split point choice algorithm for uninterrupted forecaster on I? to find the split point.3.10.2.1 Transformation of a Categorical Predictor into a Continuous ForecasterLet X be a nominal categorical forecaster taking values in the set Transform X into a uninterrupted variable such that the ratio of between-class to within-class amount of squares of is maximized ( the categories here refer to the categories of dependent variable ) . The inside informations are as follows.Transform each value ten of X into an I dimensional silent person vector, whereCalculate the overall and category J mean of V.where N is a specific instance in the whole exemplar, frequence angle associated with instance N, is the entire figure of instances and is the entire figure of instances in category J.Calculate the undermentioned IA-I matrices. actualize individual value decomposition on T to obtain where Q is an IA-I extraneous matrix, such that Let where if 0 otherwise. Perform individual value decomposition on to obtain its eigenvector which is associated with its largest characteristic root of a square matrix.The largest discriminant co-ordinate of V is the projection3.10.3 FilletThe stopping measure cheques if the tree turning procedure should be stop harmonizing to the following fillet regulations.If a node becomes virgin that is, all instances belong to the same dependant variable category at the node, the node will non be split.If all instances in a node have indistinguishable values for each forecaster, the node will non be split.If the current tree deepness reaches the user-specified maximal tree deepness bound value, the tree turning procedure will halt.If the size of a node is less than the user-specified minimal node size value, the node will non be split.If the split of a node consequences in a kid node whose node size is less than the user-specified minimal kid node size value, the node will non be split.3.11 CART Algorit hmCategorization and Regression Tree ( C & A RT ) or ( CART ) is given by Breiman et Al ( 1984 ) . CART is a binary determination tree that is constructed by dividing a node into two kid nodes repeatedly, get downing with the root node that contains the whole acquisition sample.The procedure of ciphering categorization and arrested development trees can be involved four primary stairssSpecification of Criteria for predictive AccuracySplit pickaxeStopingRight Size of the Tree A3.11.1 Specification of Criteria for Predictive AccuracyThe categorization and arrested development trees ( C & A RT ) algorithms are normally aimed at accomplishing the superior possible prognostic true statement. The outlook with the least cost is defined as most precise anticipation. The construct of cost was developed to generalise, to a wider scope of anticipation state of affairss, the idea that the best anticipation has the minimal misclassification rate. In the bulk of applications, the cost is measured in the signifier of proportion of misclassified instances, or discrepancy. In this context, it follows, hence, that a anticipation would be considered best if it has the lowest misclassification rate or the smallest discrepancy. The demand of minimising be arises when some of the anticipations that fail are more catastrophic than others, or the failed anticipations occur more frequently than others.3.11.1.1 PriorsIn the instance of a soft response ( categorization job ) , costs are minimized in order to minimise the proportion of misclassification when priors are relative to the size of the category and when for every category costs of misclassification are taken to be equal.The anterior chances those are used in minimising the costs of misclassification can greatly act upon the categorization of objects. Therefore, attention has to be taken for utilizing the priors. Harmonizing to general construct, to set the weight down of misclassification for each class the compara tive size of the priors should be used. However, no priors are required when one is constructing a arrested development tree.3.11.1.2 Misclassification Costss aroundtimes more accurate categorization of the response is required for a few categories than others for campaign non related to the comparative category sizes. If the decisive factor for prognostic legality is Misclassification costs, so minimising costs would amount to minimising the proportion of misclassification at the clip priors are taken relative to the size of categories and costs of misclassification are taken to be the same for every category. A3.11.2 Split ChoiceThe following cardinal measure in categorization and arrested development trees ( CART ) is the choice of splits on the footing of explanatory variables, used to foretell rank in instance of the categorical response variables, or for the anticipation uninterrupted response variable. In general footings, the plan will happen at each node the split that wi ll bring forth the greatest betterment in prognostic truth. This is normally measured with some type of node dross step, which gives an reading of the homogeneousness of instances in the last-place nodes. If every instance in each terminal node adorn equal values, so node dross is smallest, homogeneousness is maximum, and anticipation is ideal ( at least for the instances those were used in the computations prognostic cogency for new instances is of class a different affair ) . In simple words it can be said that bring a step of dross of a node to assist make up ones mind on how to divide a node, or which node to divideThe step should be at a fastness limit when a node is every bit divided amongst all categoriesThe dross should be zero if the node is all one category3.11.2.1 Measures of slagThere are many steps of dross but following are the good known steps.Misclassification appraiseInformation, or InformationGini IndexIn pattern the misclassification rate is non used becaus e state of affairss can happen where no split improves the misclassification rate and besides the misclassification rate can be equal when one option is clearly better for the following measure.3.11.2.2 Measure of Impurity of a NodeAchieves its upper limit at ( , ,a , ) = ( , ,a , )Achieves its lower limit ( normally zero ) when one = 1, for some I, and the remainder are zero. ( pure node )Symmetrical map of ( , ,a , )Gini indexI ( T ) = = 1 Information3.11.2.3 To Make a Split at a NodeSee each variable, ,a ,Find the split for that gives the greatest decrease in Gini index for dross i.e. maximise( 1 ) make this for j=1,2, a , PUse the variables that gives the best split, If cost of misclassification are unequal, CART chooses a split to obtain the biggest decrease inI ( T ) = C ( one J )= C ( one J ) + C ( j I ) priors can be incorporated into the costs )3.11.3 FilletIn chief, carve up could go on until all instances are absolutely classified or predicted. However, this would nt do some(prenominal) sense since one would probably stop up with a tree construction that is as multiplex and boring as the original informations file ( with many nodes perchance incorporating individual observations ) , and that would most likely non be really utile or accurate for herald new observations. What is required is some sensible fillet regulation. Two methods can be used to carry on a cheque on the splitting procedure viz. Minimum N and Fraction of objects.3.11.3.1 marginal NTo make up ones mind about the fillet of the splits, splitting is permitted to go on until all the terminal nodes are pure or they are more than a specified figure of objects in the terminal node.3.11.3.2 Fraction of ObjectsAnother manner to make up ones mind about the fillet of the splits, splitting is permitted to go on until all the terminal nodes are pure or there are a specified smallest fraction of the size of one ore more classs in the response variable.For categorization jobs, if th e priors are tantamount(predicate) and category sizes are same as good, so we will halt splitting when all terminal nodes those have more than one class, have no more instances than the defined fraction of the size of class for one or more classs. On the other manus, if the priors which are used in the analysis are non equal, one would halt splitting when all terminal nodes for which two or more categories have no more instances than defined fraction for one or more categories ( Loh and Vanichestakul, 1988 ) .3.11.4 Right Size of the TreeThe bulk of a tree in the C & A RT ( categorization and arrested development trees ) analysis is an of import affair, since an immoderately big tree makes the reading of consequences more complicated. Some generalisations can be presented about what constitutes the accurate size of the tree. It should be adequately complex to depict for the acknowledge facts, but it should be every bit easy as possible. It should use information that increases pr ognostic truth and pay no attending to information that does non. It should demo the manner to the larger apprehension of the phenomena. One try is to turn the tree up to the right size, where the size is specify by the user, based on the information from anterior research, analytical information from earlier analyses, or even perceptual experience. The other attack is to utilize a set of well-known, structured processs introduced by Breiman et Al. ( 1984 ) for the choice of right size of the tree. These processs are non perfect, as Breiman et Al. ( 1984 ) thirstily acknowledge, but at least they take internal sentiment out of the procedure to choose the right-sized tree. A There are some methods to halt the splitting.3.11.4.1 show Sample Cross-ValidationThe most preferable sort of cross-validation is the trial sample cross-validation. In this kind of cross-validation, the tree is constructed from the larning sample, and trial sample is used to look into the prognostic truth of t his tree. If test sample costs go beyond the costs for the acquisition sample, so this is an indicant of abject cross-validation. In this instance, some other sized tree may cross-validate healthier. The trial samples and larning samples can be made by taking two independent informations sets, if a larger learning sample is gettable, by reserving a randomly chosen proportion ( say one 3rd or one half ) of the instances for utilizing as the trial sample. ASplit the N units in the preparation sample into V- groups of equal size. ( V=10 )Construct a big tree and primp for each set of antlion groups.Suppose group V is held out and a big tree is built from the combined informations in the other V-1 groups.Find the best subtree for sorting the instances in group V. Run each instance in group V down the tree and calculate the figure that are misclassified.R ( T ) = R ( T ) +Number of nodes in tree Tcomplexness parametric quantityNumber misclassifiedWith tree TFind the weakest node and snip off all subdivisions formed by dividing at that node. ( examine each non terminal node )I ) Check each brace of terminal nodes and prune if13S3 F Number misclassifiedat node T= 37 S3 F6 S0 F=0 = 313S3 Fso do a terminal node.two ) Find the following weakest node. For the t-th node computeR ( T ) = R ( T ) +Number of nodesat or below node TNumber misclassifiedIf all subdivisions fromnode T are keptR ( T ) == R ( T )should snip if R ( T ) R ( T )this occurs whenat each non terminal node compute the smallest value of such thatthe node with the smallest such is the weakest node and all subdivisions below it should be pruned off. It so becomes a terminal node. Produce a sequence of treesthis is done individually for V= 1,2, a , V.3.11.4.2 V-fold Cross-ValidationThe 2nd type of cross-validation is V-fold cross-validation. This type of cross-validation is valuable when trial sample is non available and the acquisition sample is really little that test sample can non be taken from it. The figure of random bomber samples are determined by the user specified value ( called v value ) for V-fold cross make. These sub samples are made from the acquisition samples and they should be about equal in size. A tree of the specified size is calculated v A times, each clip go forthing out one of the bomber samples from the calculations, and utilizing that sub sample as a trial sample for cross-validation, with the pop the question that each bomber sample is considered ( 5 1 ) times within the learning sample and merely one time as the trial sample. The cross proof costs, calculated for all v trial samples, are averaged to show the v-fold estimation of the cross proof costs.